Table 4.
Moderation analysis (controlling for other genotypes and age).
| Gene predictor | Outcome | Maternal moderator variable | Moderator value: conditional effect of genotype on outcome B (LLCI;ULCI) | Model parameters | Interaction effect B (LLCI;ULCI) |
|---|---|---|---|---|---|
| GSTA1 | ADI-R_D | Medication in pregnancy | Present: −0.837 (−1.446; −0.227)† Not present: 0.591 (0.007; 1.174)† |
R2 = 0.167 F = 2.342* |
−1.427 (−2.275;−0.5801)† |
| Patient currently taking medication | Smoking in pregnancy | Present:−3.593 (−6.293; −0.892)† Not present:−0.032 (−1.148; 1.085) |
Cox&Snell R2 = 0.273 Nagelkerke R2 = 0.364 X2 = 30.322** |
−3.561 (−6.592; −0.528)† | |
| GSTM1 | VIN | Smoking in pregnancy | Present:−4.785 (−16.550; 6.980) Not present: 13.321 (5.501; 21.141)† |
R2 = 0.565 F = 12.262** |
−18.106 (−32.263; −3.949)† |
| GSTT1 | Seizures | Medication in pregnancy | Present: −2.814 (−5.356; −0.271)† Not present: 1.031 (−1.661; 3.723) |
Cox&Snell R2 = 0.266 Nagelkerke R2 = 0.463 X2 = 30.361** |
−3.845 (−7.596; −0.093) |
*
< 0.05;
**
< 0.01;
†
Significant bootstrapping confidence intervals; ADI-R_D, ADI-R diagnostic score D; Seizures, seizures present/not present; VIN, Vineland adaptive composite score; Hospitalizations No, number of hospitalizations.