Figure 4.
Brain tissue slices for (A) untreated rats and rats treated with (B) naked siRaf-1, (C) CPT-loaded MPEG-PCL-Tat/siControl, (D) MPEG-PCL-Tat/siRaf-1, and (E) CPT-loaded MPEG-PCL-Tat/siRaf-1. The greatest reduction in tumor size was seen with the peptide modified polymer micelle loaded with both drug and gene therapeutics. Reprinted with permission from reference.142 Copyright 2014 American Chemical Society.