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. 2021 Jul 2;22(13):7176. doi: 10.3390/ijms22137176

Figure 2.

Figure 2

Coordinated temporal activation of factors important for MZB cell emigration from splenic marginal zone (MZ) areas to the salivary glands of C57BL/6.NOD-Aec1Aec2 mice at onset of SS-like disease. Transcriptomic data reveal that genes encoding ICAM1 and VCAM1 (Receptors for LFA1), LFA-1 (ItgaL and Itgβ2), Cxcl13, Cxcr5 (the Cxcl13 receptor), Dock2, Ccr6, Ccr7, and Ptk2β are all upregulated in the salivary glands of C57BL/6.NOD-Aec1Aec2 mice at 16 weeks of age (right panel), the approximate time point when the immune response is transitioning to the adaptive immune response phase. In contrast, no similar upregulated expressions of these genes are seen in the salivary glands of C57BL/6J mice (left panel).