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. 2021 Jul 2;22(13):7176. doi: 10.3390/ijms22137176

Figure 5.

Figure 5

Upregulated profiles of genes encoding for members of the Rho-GTPase Dock family of proteins. Transcriptome data showing the temporal expressions of the Dock genes upregulated in the salivary glands of C57BL/6.NOD-Aec1Aec2 mice (lower panel) versus C57BL/6J mice (upper panel). In the SS-susceptible C57BL/6.NOD-Aec1Aec2 mice three genes, Dock2, Dock10, and Dock11, reported to be uniquely associated with B and T lymphocyte functions, exhibit a concomitant upregulated short-term expression at 16 weeks of age (arrows), while Dock1, 5, 7 and 8 are each upregulated starting at 4 weeks of age and remain activated out to 16 or 20 weeks of age. In contrast, in the SS-non-susceptible C57BL/6J mice, Dock4, 7, 9, 10 and 11 exhibit an upregulated expression starting at 4 weeks of age, while Dock8 shows a unique expression pattern being upregulated at 16 weeks of age.