Figure 6.

Rho-Arhgef pathway activations. Rho-Arhgef molecules are associated with several signal transduction pathways including Rac-GTP, Rho-GTP and CDC42-GP, each leading to downstream activation of a biological process important for cellular migrations. These three pathways interact, respectively, with Wasf, Rock, and Was protein family members. In the salivary glands of C57BL/6.NOD-Aec1Aec2 mouse these appear to be Wasf3, Rock1, Rock2 and Was (right panel). The genes encoding Wasf3, Rock1 and Rock2 show an activation starting at 4 weeks of age, while the gene encoding Was is upregulated uniquely at 16 weeks of age. In the salivary glands of C57BL/6J mice, a strong activation is observed with Wasf3, and possibly a weak response by Rock1.