Figure 7.

Temporal and differential gene expressions of various factors involved with signal transduction pathways regulated by members of the Rho-GTPase families of proteins. Transcriptome data of multiple genes (i.e., Cdc42, Vav, and Baiap (brain-specific angiogenesis inhibitor -1 associated protein) family members, plus Scrib1, Setd6, Grb2, Flii, Creb3 and Foxo3a) exhibit upregulated expressions in the salivary glands of C57BL/6.NOD-Aec1Aec2 mice, virtually all starting at 8 weeks of age (lower panel). C57BL/6J mice exhibit a general lack of upregulated expression, except for Vav1 and possibly Cdc42bpg and Vav2 (upper panel).