Table 4.
Weighted averages of clinical outcomes of patients treated with autologous chondrocyte implantation using spheroids.
| Score | Lead Author (Year) | Value | Patients (n) |
|---|---|---|---|
| Overall KOOS | Niemeyer (2020) [12] | 77.1 ± 18.6 | 73 |
| Hoburg (2020) [14] | 83.2 ± 14.9 | 48 | |
| Siebold (2014) [16] | 74.4 ± 16.9 | 10 | |
| Siebold (2016) [17] | 69.76 | 31 | |
| Siebold (2018) [18] | 78.7 | 30 | |
| Hoburg (2019) [19] * | 82.6 ± 11.6 | 29 | |
| Weighted average | 78.2 | 221 | |
| MOCART | Niemeyer (2020) [12] | 75.5 ± 13.1 | 69 |
| Fickert (2012) [15] | 70 | 14 | |
| Hoburg (2019) [19] * | 74.7 ± 12 | 29 | |
| Niemeyer 2016 [10] § | 76 ± 16 | 46 | |
| Weighted average | 75.0 | 158 | |
| IKDC | Niemeyer (2020) [12] | 74.6 ± 18.7 | 73 |
| Fickert (2012) [15] | 64 | 37 | |
| Siebold (2014) [16] | 63.9 ± 22.1 | 10 | |
| Siebold (2016) [10] | 63 ± 18.8 | 31 | |
| Siebold (2018) [18] | 84.2 ± 5.6 | 30 | |
| Hoburg (2019) [19] * | 81.1 ± 17.7 | 22 | |
| Weighted average | 72.5 | 203 | |
| Lysholm | Fickert (2012) [15] | 82.5 | 37 |
| Siebold (2014) [16] | 74.1 ± 18.7 | 10 | |
| Siebold (2016) [17] | 79 ± 18 | 31 | |
| Siebold (2018) [18] | 77.7 ± 14.6 | 30 | |
| Weighted average | 79.4 | 108 |
* Only the adolescent subgroup is included as the young adults are a subgroup of the phase II clinical trial [10,12]. § same study as Hoburg (2020) [14]. KOOS: Knee injury and osteoarthritis outcome score. MOCART: Magnetic resonance observation of cartilage repair tissue. IKDC: International knee documentation committee.