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. 2021 Jun 24;13(13):3155. doi: 10.3390/cancers13133155

Figure 8.

Figure 8

Mutations in genes encoding subunits of the SWI/SNF and COMPASS-like complexes correlate with sensitivity to PRC2 knockout. (A) EZH2, (B) SUZ12 and (C) EED. The X-axis shows the dependency scores of the lines with alterations of a particular gene (orange, grey and yellow circles) vs. all cell lines (blue circles, 777 in total). Black bold vertical line indicates the dependency score −0.5 (the score <−0.5 mean that gene is critical for cells survival). p-value—the statistical significancy for hypothesis that the cell lines with SWI/SNF or COMPASS mutations will have a score of less than −0.5. The number of cancer cell lines bearing an altered gene with a score <−0.5/total number of cell lines bearing the altered gene is indicated at the right.