Table 2.
The Top Co-dependency Pearson correlations upon knockout of PRC2 components by CRISPR/Cas9 technology in tumor cell lines (DepMap project data). Bold—subunits of PRC2 complex.
| Top 5 Co-Dependencies upon EZH2 Deletion | Top 5 Co-Dependencies upon SUZ12 Deletion | Top 5 Co-Dependencies upon EED Deletion | ||||||
|---|---|---|---|---|---|---|---|---|
| Rank | Gene | Pearson Correlation | Rank | Gene | Pearson Correlation | Rank | Gene | Pearson Correlation |
| 1 | EED | 0.67 | 1 | EED | 0.64 | 1 | EZH2 | 0.67 |
| 2 | SUZ12 | 0.61 | 2 | EZH2 | 0.61 | 2 | SUZ12 | 0.64 |
| 3 | DOT1L | 0.41 | 3 | RING1 | 0.37 | 3 | DOT1L | 0.40 |
| 4 | RING1 | 0.36 | 4 | PCGF1 | 0.32 | 4 | RING1 | 0.36 |
| 5 | PCGF1 | 0.33 | 5 | DOT1L | 0.29 | 5 | MEN1 | 0.35 |