. 2021 Jun 29;10(13):2905. doi: 10.3390/jcm10132905

Table 5.

The relationship between markers of bone turnover and osteoclastogenesis markers as well as PINP/CTX-I, sRANKL/OPG ratios, and clinical and laboratory indicators of disease activity in women with rheumatoid arthritis at the baseline and after 15 months of anti-TNF-α therapy.

Parameter	RA Patients (n = 31) Time after Initiation of TNFαI Therapy
	Baseline (T₀)
	PINP	CTX-I	PINP/CTX-I	sRANKL	OPG	sRANKL/OPG
CRP	−0.167 ^NS	−0.216 ^NS	0.03 ^NS	0.238 ^NS	−0.05 ^NS	0.302 ^NS
ESR	0.044 ^NS	−0.075 ^NS	0.213 ^NS	0.247 ^NS	0.233 ^NS	0.176 ^NS
DAS28-ESR	0.012 ^NS	−0.216 ^NS	0.132 ^NS	−0.221 ^NS	0.07 ^NS	−0.207 ^NS
SJC	−0.130 ^NS	−0.223 ^NS	0.068 ^NS	−0.307 ^NS	0.001 ^NS	−0.305 ^NS
TJC	−0.027 ^NS	0.0245 ^NS	−0.088 ^NS	−0.044 ^NS	−0.236 ^NS	−0.320 ^NS
VAS	0.105 ^NS	0.146 ^NS	−0.097 ^NS	−0.047 ^NS	0.101 ^NS	−0.160 ^NS
	15 Months (T₃)
CRP	−0.08 ^NS	0.319 ^NS	−0.333 ^NS	−0.03 ^NS	−0.128 ^NS	0.059 ^NS
ESR	0.202 ^NS	0.067 ^NS	0.145 ^NS	0.169 ^NS	0.285 ^NS	0.091 ^NS
DAS28-ESR	0.185 ^NS	0.112 ^NS	0.054 ^NS	0.193 ^NS	0.255 ^NS	0.077 ^NS
SJC	0.353 ^NS	0.085 ^NS	0.097 ^NS	0.000 ^NS	−0.036 ^NS	0.012 ^NS
TJC	−0.028 ^NS	−0.028 ^NS	0.0176 ^NS	0.097 ^NS	−0.214 ^NS	0.051 ^NS
VAS	0.082 ^NS	0.040 ^NS	−0.047 ^NS	0.071 ^NS	0.322 ^NS	−0.091 ^NS

Results are expressed as r (correlation coefficient) according to Spearman rank correlation. Correlations were considered significant at: p < 0.0083 by applying a Bonferroni correction. DAS 28-ESR, disease activity score 28; CTX-I, C-terminal cross-linking telopeptides of type I collagen; ESR, erythrocyte sedimentation rate; ^NS, not significant; OPG, osteoprotegerin; PINP, N-terminal propeptides of type I procollagen; RA, rheumatoid arthritis; SJC, swollen joint count; sRANKL, total soluble receptor activator of nuclear factor κB ligand; TJC, tender joint count; TNFαΙ, tumor necrosis factor α inhibitors.