Figure 6.

The mutation patterns in the studied genes in the samples collected from patients at the time of AML diagnosis. (A) mutations in the BCL2 family members (yellow background) and genes encoding proteins interacting with BCL2L1 (blue background); (B) mutations in the genes encoding splicing-related proteins; (C) mutations in other genes, which are recurrently mutated in AML. The presence of a mutation is indicated by a colored square. The numbers inside squares reflect the pathogenicity scores (PS) estimated by eVai software (the higher PS, the more significant the mutation). If more than one mutation was detected in a sample, the highest PS value is presented. The lack of a number means no PS score assigned to a variant (PS NA). In panel (A), all genes with a mutation in at least one sample are shown, whereas in panels (B,C), only genes with PS-assigned mutations are presented. Tables S7 and S8 contain full lists of variants detected in the studied genes and analyzed samples.