Table 6.
Results from Adjusted Cox Proportional Hazard Regression Models of Impact of the Presence of ctDNA Mutations on Overall Survival.
| 6-Gene Analysis | 3-Gene Analysis | 2-Gene Analysis | |||||||
|---|---|---|---|---|---|---|---|---|---|
| HR | 95% CI | p Value | HR | 95% CI | p Value | HR | 95% CI | p Value | |
| ctDNA mutations |
1.62 | (0.99–2.65) | 0.053 | 1.85 | (1.10–3.12) | 0.020 | 1.87 | (1.02–3.43) | 0.042 |
| p value for Adjusted Variables | p value for Adjusted Variables | p value for Adjusted Variables | |||||||
| Age Below 60 Years Old (yes vs. no) |
0.65 | 0.70 | 0.64 | ||||||
| Smoking (never vs. ever) |
0.41 | 0.54 | 0.55 | ||||||
| N Stage (N0 vs N1, N2, N3) | 0.33 | 0.49 | 0.31 | ||||||
| Subsite (OP vs. OC, Pharynx, Other) |
0.02 | 0.02 | 0.04 | ||||||
| CRT Prior to ctDNA Test (yes vs. no) |
<0.01 | <0.01 | <0.01 | ||||||
Analyses with p < 0.05 are bolded in italics and underlined; results with 0.05 < p < 0.10 are italicized and underlined. Abbreviations: CI, Confidence interval; ctDNA, circulating tumor DNA; HR, hazard ratio; CI, hazard ratio confidence interval; CS, chi-squared analysis; N/A, non-applicable; CRT, combined chemotherapy and radiation therapy; OC, oral cavity; OP, oropharynx.