Table 2.
Age of patients, histological diagnosis and HPV infection by E6/E7 PCR using tissue specimens.
| Cases with a Single Lesion | Cases with Multiple Lesions | ||||||||
|---|---|---|---|---|---|---|---|---|---|
| Diagnosis | VaIN1 | VaIN2/3 | VaSCC | VaIN1+CIN1/Con | VaIN1+CIN2/3 | VaIN2/3+CIN/Con | Total | ||
| N = 23 | N = 14 | p¹ | N = 7 | p 2 | N = 7 | N = 16 | N = 3 | N = 70 | |
| Age | 43.8 (27–67) | 48.3 (22–55) | >0.1 | 81.7 (76–88) | 0.013 | 36.6 (19–55) | 37.8 (22–80) | 42.4 (32–50) | 48.6 (19–88) |
| HPV prevalence (%) | 95.7 (22/23) | 100 (14/14) | >0.1 | 85.7 (6/7) | 85.6 (6/7) | 100 (16/16) | 100 (3/3) | 95.7 (67/70) | |
| HR-HPV (%) * | 17.4 (4/23) | 85.7 (12/14) | 57.1 (4/17) | 28.6 (2/7) | 93.8 (15/16) | 66.7 (2/3) | 55.7 (39/70) | ||
| VaIN1 CIN1/Con |
VaIN1 CIN2/3 |
VaIN2/3 CIN/Con |
|||||||
| 0 (0/7) 28.6 (2/7) |
6.25 (1/16) 87.5 (14/16) |
66.7 (2/3) 33.3 (1/3) |
|||||||
| Possible HR-HPV (%) * | 34.8 (8/23) | 0 (0/14) | 28.6 (2/7) |
57.1 (4/7) | 43.8 (7/16) | 33.3 (1/3) | 31.4 (20/70) | ||
| VaIN1 CIN1/Con |
VaIN1 CIN2/3 |
VaIN2/3 CIN/Con |
|||||||
| 42.9 (3/7) 28.6 (2/7) |
43.8 (7/16) 12.5 (2/16) |
33.3 (1/3) 33.3 (1/3) |
|||||||
| LR-HPV (%) * | 43.5 (10/23) | 14.3 (2/14) | 0 (0/7) | 42.9 (3/7) | 25.0 (4/16) | 66.7 (2/3) | 30.0(21/70) | ||
| VaIN1 CIN1/Con |
VaIN1 CIN2/3 |
VaIN2/3 CIN/Con |
|||||||
| 42.9 (3/7) 28.6 (2/7) |
25.0 (4/16) 0 (0/16) |
33.3 (1/3) 33.3 (1/3) |
|||||||
| Single HPV type (%) | 95.7 (22/23) | 78.6 (11/14) | 85.7 (6/7) | 14.3 (1/7) | 25.0 (4/16) | 0 (0/3) | 62.9(38/70) | ||
| Multiple HPV types (%) | 0 (0/23) | 21.4 (3/14) | 0 (0/7) | 71.4 (5/7) | 75.0 (12/16) | 100 (3/3) | 32.9(23/70) | ||
*: Numbers of HPV types identified as one of the multiple HPV types are repeatedly counted. CIN, cervical intraepithelial neoplasia; Con, condyloma; HPV, Human papillomavirus; HR-HPV, High risk-HPV; LR-HPV, Low risk-HPV; N, number; VaSCC, vaginal squamous cell carcinoma; VaIN, vaginal intraepithelial neoplasia. p¹ value means comparing the age, and the prevalence of any HPV type between VaIN1 and VaIN2/3 cases. p2 value means comparing the age between all VaIN and VaSCC cases.