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. 2021 Jul 5;10(13):2994. doi: 10.3390/jcm10132994

Figure 1.

Figure 1

Protein hormone levels for select T2DM pathway members in the Fr Ctx of Ts65Dn mice and 2N littermates in relation to MCS. (A) APN levels were significantly downregulated in Ts mice compared to 2N littermates. Partial rescue was found with MCS in 2N+ and Ts+ mice, as APN levels were upregulated relative to offspring from a choline normal diet. (B) Insulin levels were not differentially regulated by genotype or diet in Fr Ctx. (C) Leptin levels were not differentially regulated by genotype or diet in Fr Ctx (Error bars are standard error of mean (SEM); * p < 0.05, ** p < 0.01, *** p < 0.001).