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Adenoviral cytotoxicity in miR-21, miR-93, and miR-222 KO PANC-1 and MIA PaCa-2 cell lines. Control and miR-21 KO (A), miR-93 KO (B), and miR-222 KO (C) cells were infected with a dose range of Adwt. Cell viability was measured at 7 days post-infection (PI) by MTT assay, and infectious dose (ID50) values were determined. Data are shown as mean ± SEM for at least 3 independent biological replicates. Significance was assessed using a two-tailed Mann-Whitney test. ** p < 0.01.
