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miR-125b and miR-155 are involved in immune dysregulation in DS. Both miR-125b and miR-155 are located on chromosome 21. miR-125b is overexpressed in plasma cells, while miR-155 is overexpressed in both plasma and memory B cells, leading to an impaired humoral response. miR-155 overexpression results in reduced expression of factor H and Myd88, leading to impaired complement response and impaired inflammatory response, respectively.
