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. 2021 Jun 25;9:707319. doi: 10.3389/fbioe.2021.707319

FIGURE 3.

FIGURE 3

Schematic representation of multifunctional micellar nanocarriers triggered by acidic pH. (A) Schematic illustration of acetal- and TAT-PEO-bP(CL-g-SP) (I and II) and acetal- and RGD4C-PEO-bP(CL-Hyd- DOX) (III and IV). (B) Rational design of a multifunctional micellar nanomedicine for cancer-targeted co-delivery of MDR-1 siRNA and DOX to overcome multidrug resistance. DOX release from NON-micelles triggered by acidic pH. Reprinted from Xiao-Bing Xiong and Afsaneh Lavasanifar. Traceable Multifunctional Micellar Nanocarriers for Cancer-Targeted Co-delivery of MDR-1 siRNA and Doxorubicin. ACS Nano. 2011;5(6):5202–13. With the permission of ACS publications/from reference [105]. MDR, multidrug resistance; PEO, poly(ethylene oxide); RGD, Arg-GLT-Asp (the integrin αvβ3-specific ligand); DOX, doxorubicin; TAT, trans-activating transcriptional activator.