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. 2021 Jun 25;9:707319. doi: 10.3389/fbioe.2021.707319

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Copyright © 2021 Chang, Ma, Xu, Xie and Ju.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Schematic illustration of dual redox-responsive micelles. (A) Chemical structure of mPEG-b-P(Des-alt-Cys) copolymer and (B) dual redox-responsive micelles and CPT release triggered by ROS and GSH. The dual redox-responsive micelles enter into cancer cells and exhibited high levels of ROS and GSH, then the structures of micelles are deformed, and the encapsulated CPT could be liberated from micelles, leading to selectively location-controlled drug release. Reprinted from Yi-Ting Chiang, Yu-Wei Yen, and Chun-Liang Lo. Reactive oxygen species and glutathione dual redox-responsive micelles for selective cytotoxicity of cancer. Biomaterials. 2015;61:150–61. With permission from reference (Chiang et al., 2015). PEG, poly(ethylene glycol); Des, diethyl sulfide; Cys, cystamine; CPT, camptothecin; ROS, reactive oxygen species; GSH, glutathione.