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. 2021 Jun 25;9:707319. doi: 10.3389/fbioe.2021.707319

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Copyright © 2021 Chang, Ma, Xu, Xie and Ju.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Schematic illustration of a drug-loaded hypoxia-responsive polymer nanoparticle. The hypoxia-responsive polymers can reach the tumor site via the EPR effect, followed by intracellular drug release at hypoxic tissue. Reprinted from Thavasyappan Thambi, V.G. Deepagan, Hong Yeol Yoon, et al. Hypoxia-responsive polymeric nanoparticles for tumor-targeted drug delivery. Biomaterials. 2014;35(5):1735–43. With permission from reference (Thambi et al., 2014). NPs, nanoparticles; EPR, enhanced permeation and retention; DOX, doxorubicin.