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. 2021 Jun 25;9:707319. doi: 10.3389/fbioe.2021.707319

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Copyright © 2021 Chang, Ma, Xu, Xie and Ju.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Schematic Illustration of the temperature-responsive polymer systems. (A) The Au NPs were functionalized with freshly reduced pNIPAAm-co-pAAm copolymer (p), and the thermal response-based aggregation was measured. (B) The Au NPs were first functionalized with thiolated A-type ssDNA, then co-functionalized with p. The assembly of Ap-Au with complementary A’-Au was then blocked at T < T_C (C), but promoted at T > T_C (D). Reprinted from Hamner KL, Alexander CM, Coopersmith K, et al. Using temperature-sensitive smart polymers to regulate DNA-mediated nanoassembly and encoded nanocarrier drug release. ACS Nano. 2013;7(8):7011–20. With permission from reference (Hamner et al., 2013). Au NPs, gold nanoparticles; Tc, critical temperature.