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. 2021 Jun 25;12:676414. doi: 10.3389/fmicb.2021.676414

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Copyright © 2021 Feng, Liu, Wang, Zhang, Sun, Li, Wang, Liu and Cao.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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The combination of colistin and auranofin shows potency in vivo. (A,B) Mice were infected by high-level Col-R K. pneumoniae 18605 and received single dose of i.p. administration of vehicle, colistin sulfate, auranofin, or their combination (n = 8 per group). Bacterial loads in the PF (A) and spleen (B) are shown. (C) Survival curves showing combination efficacies in the peritoneal infection model. Mice were infected by a lethal dose of high-level Col-R A. baumannii 13660 and treated with one dose at 0.5 h post infection, followed by once-daily treatment with i.p. vehicle, colistin sulfate, auranofin, or the combination (n = 8 per group). ****indicates p ≤ 0.0001, ***indicates p ≤ 0.001, compared with the control group.