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. 2021 Jul 1;22(13):7130. doi: 10.3390/ijms22137130

Table 7.

Antimicrobial studies performed with curcumin in polymeric drug delivery systems.

Type of Polymeric DDS [CUR] Formulation Microorganism Type of Culture Antimicrobial Method Antimicrobial [CUR] Light/Ultrasonic Parameters Reference
PEG 400
γ-CD and PEG + β-CD
0.18% E. faecalis
E. coli
Planktonic CFU/mL
aPDT
N/R 9.7 J/cm2
29 J/cm2
[158]
CUR-NP without polymer 100 mg S. aureus
B. subtillis
E. coli
P. aeruginosa
P. notatum
A. niger
Planktonic MIC
Inhibition zone
100 mg
0.27 mmol
- [159]
CUR-NP without polymer 100 mg M. lutues
S. aureus
E. coli
P. aeruginosa
Planktonic MBC N/R - [160]
Mixed polymer NP 5 mM E. coli Planktonic MIC 400–500 μM - [161]
CTAB
Tween 20
Sodium dodecylsulfate
100 mg/mL L. monicytogenes Planktonic Inhibition zone N/R - [162]
PLA/dextran sulfate 4 mg/mL MRSA
C. albicans
S. mutans
Planktonic/mono- and –mixed biofilm aPDT 260 μM 43.2 J/cm2 [163]
PLA/dextran sulfate 0.4% C. albicans Animal model aPDT 260 μM 37.5 J/cm2 [164]
Nanocurcumin N/R P. aeruginosa (isolates) and standard strain Planktonic MIC 128 µg/mL - [165]
PLGA 5 mg S. saprophyticus subsp. Bovis
E. coli
Planktonic aPDT 50 µg/mL 13.2 J/cm2 [166]
Eudragit L-100 N/C L. monocytogenes Planktonic Animal model infection N/R - [167]
nCUR N/R S. mutans Planktonic
Biofilm
Inhibition zone
aPDT
N/R 300–420 J/cm2 [168]
nCUR combined with indocyanine 100 mg E. faecalis Biofilm Metabolic activity N/R 500 mW/cm2 [169]
PVAc-CUR-PET-PVDC 0.02 g S. aureus
S. tiphimurium
Planktonic aPDT N/R 24, 48, and 72 J/cm2 [170]
MOA.CUR-PLGA-NP Up to 10% S. mutans Biofilm aPDT 7% wt 45 J/cm2 [171]
CS- β-CD N/C S. aureus
E. coli
Planktonic Colony count Up to 0.03% - [172]

[CUR]: CUR concentration. -: not performed. N/R: not reported. N/C: not clear.