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. 2021 Jun 24;143(26):9872–9883. doi: 10.1021/jacs.1c03772

Figure 2.

Figure 2

Synthesis of polymerizable squaric ester amides. (A) General chemical structure of synthesized monomers with a pendant squaric ester amide group. (B) Synthesis route toward the most suitable monomer squaric ester amide methacrylamide (MA-SQ). (C) Schematic illustrations and (D) synthesis schemes of RAFT homopolymerization of MA-SQ with a small molecular trithiocarbonate chain transfer agent (TTC-CTA) (C1 and D1) and block copolymerization with macro-chain-transfer agent PEG-TTC-CTA (C2 and D2) (reaction conditions: (i) DMF, 70 °C, 0.2 equiv AIBN per 1.0 equiv TTC-CTA, and (ii) DMF, 70 °C, 50 equiv AIBN (to remove the TTC end group)). (E) Molecular weight distributions of polymers obtained by radical polymerization: (E1) RAFT-derived homopolymer compared to the homopolymer obtained by FRP; (E2) RAFT-derived block copolymer compared to PEG-TTC-CTA as macro-chain-transfer agent.