FIGURE 5.

Summary of IHH-induced differentially expressed genes (DEGs) in the hearts of CONV and GF mice. (A) Distribution of DEGs in GF and CONV mice following IHH exposure. Note that a significantly larger proportion of the alterations >5-fold was detected in the CONV mice as compared to that in the GF mice (p < 0.05, chi-square test). Blue bar: up-regulations; yellow bar: down-regulations. (B) IHH exposure-induced common transcriptional alteration between GF and CONV mice, where 3 DEGs were upregulated and 14 DEGs were downregulated in both CONV and GF mice. Two other DEGs were downregulated in CONV but upregulated in GF mice. Red circles with blue fill-in: upregulations; green circles with yellow fill-in: downregulations. Overlaps: number of common changes observed in both CONV and GF mice. (C) Transcriptional abundance of the common DEGs in GF and CONV mice in room air or under IHH condition (| Fold change| > 1.5, Benjamini–Hochberg adjusted p < 0.05).