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. 2021 Jun 25;12:680275. doi: 10.3389/fphys.2021.680275

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Copyright © 2021 Zhou, Xue, Miyamoto, Poulsen, Eckmann and Haddad.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Top significantly altered pathways in the heart of CONV and GF mice following intermittent hypoxia/hypercapnia exposure. The canonical pathways that were significantly altered by IHH exposure in CONV and GF mice were determined with IPA. (A) The top 10 significantly altered pathways in CONV mice. (B) The top 10 significantly altered pathways in GF mice. The statistical significance was calculated with right-tailed Fisher’s exact test; a p-value < 0.05 was considered significant.