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. 2021 Jun 25;12:685698. doi: 10.3389/fmicb.2021.685698

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Copyright © 2021 Stærk, Grønnemose, Palarasah, Kolmos, Lund, Alm, Thomsen and Andersen.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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A conceptual schematic. (A–C) The interpenetrating polymer network (IPN)-silicone facilitates concentration-dependent drug molecule migration from one side of the material to the other. (D) When implemented into a Foley-type catheter balloon, the balloon is inflated with a drug solution through the balloon port. (E) Once inflated, the balloon provides dual functionality by (i) ensuring anchorage of the catheter within the bladder and (ii) providing a drug reservoir capacity for controlled drug-release into the urine.