Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2021 Jun 25;12:676644. doi: 10.3389/fimmu.2021.676644

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

Copyright © 2021 Phelan, Shigemura, Aldhafiri, Mota, Hall, Sznajder, Murphy, Crean and Cummins

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

PMC Copyright notice

Knockdown of NR4A2 alters MHC Class1 gene expression. RAW TPM values (mean +/- SEM) extracted from RNA-seq for genes associated with MHC-Class I (green rectangles) and MHC-Class II (purple rectangles). Data shown for HLA-B (A) HLA-C (B) HLA-F (C) HLA-DRA (D) HLA-DRB1 (E) and HLA-DPB1 (F) in shNT-THP1 cells, shNR4A2-THP1 cells and shNR4A3-THP1 cells in the control (unstimulated state) and following LPS treatment (2.5μg/ml for 2hrs). N=3 independent experiments. Adjusted p-values (Padj) for specific comparisons are contained in the tables below the TPM data. Statistically significant Padj are denoted in bold font. Comparisons between shNR4A2 cells and control are denoted in the red boxes, comparisons between the shNR4A3 cells and control are denoted in the blue boxes. Statistically significant comparisons are further signposted using bars on the TPM graphs.