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. 2021 Jun 25;12:676644. doi: 10.3389/fimmu.2021.676644

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Copyright © 2021 Phelan, Shigemura, Aldhafiri, Mota, Hall, Sznajder, Murphy, Crean and Cummins

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Knockdown of NR4A3 has a distinct transcriptional profile in the presence of LPS. Principal component analysis (PCA) plot of transduced cells based on RNA-seq data between shNT and shNR4A3 in the presence of LPS cells (A). Volcano plot of significant DEGs (p<0.05) upregulated (log2fc>/=1) (green) or downregulated (log2fc</=-1) (red) by knockdown of NR4A3 in THP-1 cells in the presence of LPS based on RNA-seq data (B). Top gene ontology (GO) terms associated with knockdown of NR4A3 in THP-1 cells in the presence of LPS based on RNA-seq data (C). Summary table of significant DEGs upregulated (green) and downregulated (red) by knockdown of NR4A3 in THP-1 cells in the presence of LPS based on RNA-seq data (D).