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. 2021 Jun 25;11:672684. doi: 10.3389/fonc.2021.672684

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Copyright © 2021 Zhang, Li, Zhao, Yang, Sang, Yan, Wang and Li

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Overexpressing THEM4 dampened the malignant phenotypes of CC. THEM4 overexpression model was established on SW480 cells. (A) The THEM4 expression was detected by WB. (B) CCK-8 assay was employed to examine CC cell proliferation. (C) Colony formation assay was applied to detect the ability of cells to form colonies. (D) Wound healing test determined cell migration. (E) Cell invasion was monitored by Transwell assay. (F) Apoptosis was determined by FCM. (G) Akt and NF-κB levels were compared by WB. *P < 0.05, **P < 0.01, ***P < 0.001 (vs. The M2-TAM ^miR-NC group). N=3.