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. 2021 Jun 25;11:672684. doi: 10.3389/fonc.2021.672684

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Copyright © 2021 Zhang, Li, Zhao, Yang, Sang, Yan, Wang and Li

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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miR-183-5p enriched M2-TAM-Exo heightened the proliferation and metastasis of CC cells in vivo. The xenograft model was constructed to observe the effect of miR-183-5p in vivo. (A) The figure of xenograft tumor. (B, C) Tumor volume and weight. (D) H&E staining. (E) The miR-183-5p profile in the xenograft tumor was determined verified by qRT-PCR. (F, G) The levels of Ki67 and THEM4 were compared by IHC. (H) The relative expression of THEM4, AKT and p-NF-κB in tumor tissues of each group was tested by WB. *P <0.05, **P < 0.01, ***P <0.001 (vs. M2-TAM group). N=3.