Table 4.
Uptake intensities of 18F-FDG and 68Ga-FAPI-04 in positive lesions.
| Characteristic | 18F-FDG | 68Ga-FAPI-04 | ||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| No. | SUVmax | P | TBR | P | No. | SUVmax | P | TBR | P | |
| All | 20 | 5.89 ± 3.38 | 3.14 ± 1.59 | 30 | 6.96 ± 5.01 | 11.90 ± 8.35 | ||||
| Clinical features | ||||||||||
| Cirrhosis | 16 | 5.43 ± 2.79 | 0.706 | 3.09 ± 1.57 | 0.925 | 24 | 7.29 ± 5.27 | 0.351 | 11.33 ± 8.41 | 0.300 |
| Non-cirrhosis | 4 | 7.77 ± 5.25 | 3.32 ± 1.92 | 6 | 5.61 ± 3.91 | 14.15 ± 8.47 | ||||
| AFP (ng/mL) | ||||||||||
| ≤ 20 | 11 | 4.92 ± 2.55 | 0.239 | 2.60 ± 1.32 | 0.119 | 17 | 7.02 ± 5.27 | 0.818 | 10.72 ± 6.33 | 0.517 |
| > 20 | 9 | 7.09 ± 4.01 | 3.79 ± 1.73 | 13 | 6.88 ± 4.86 | 13.44 ± 10.52 | ||||
| Tumour number | ||||||||||
| Solitary tumour | 10 | 7.15 ± 4.26 | 0.326 | 3.73 ± 1.98 | 0.326 | 14 | 8.53 ± 6.43 | 0.271 | 14.69 ± 9.73 | 0.074 |
| Multiple tumours | 10 | 4.64 ± 1.58 | 2.54 ± 0.81 | 16 | 5.58 ± 2.89 | 9.45 ± 6.26 | ||||
| MVI | ||||||||||
| M0 + M1 | 4 | 3.64 ± 0.86 | 0.048* | 2.02 ± 0.47 | 0.120 | 10 | 4.86 ± 2.04 | 0.852 | 10.45 ± 4.52 | 0.804 |
| M2 | 10 | 7.16 ± 3.74 | 3.48 ± 1.58 | 13 | 5.85 ± 3.69 | 11.60 ± 8.78 | ||||
| AJCC TNM staging | ||||||||||
| I | 0 | – | 0.093 | – | 0.121 | 4 | 4.07 ± 2.59 | 0.404 | 6.73 ± 2.36 | 0.194 |
| II | 8 | 4.92 ± 2.96 | 2.64 ± 1.53 | 12 | 4.99 ± 2.54 | 10.27 ± 5.70 | ||||
| III + IV | 6 | 7.79 ± 3.85 | 3.63 ± 1.37 | 7 | 6.94 ± 3.87 | 15.03 ± 9.56 | ||||
| Diameter (cm) | ||||||||||
| ≤ 2 | 3 | 3.17 ± 0.49 | 0.079 | 1.90 ± 0.36 | 0.215 | 11 | 4.17 ± 2.75 | 0.023* | 7.56 ± 3.62 | 0.019* |
| > 2, ≤ 5 | 9 | 5.91 ± 3.42 | 3.46 ± 1.89 | 11 | 7.84 ± 4.28 | 12.12 ± 10.15 | ||||
| > 5 | 8 | 6.89 ± 3.65 | 3.23 ± 1.39 | 8 | 9.58 ± 6.77 | 17.55 ± 7.56 | ||||
| Histologic grade | ||||||||||
| I + II | 4 | 3.74 ± 0.82 | 0.045* | 1.93 ± 0.44 | 0.045* | 10 | 4.62 ± 2.10 | 0.391 | 10.17 ± 4.70 | 0.895 |
| III + IV | 9 | 7.55 ± 3.74 | 3.66 ± 1.57 | 12 | 6.26 ± 3.67 | 11.90 ± 9.05 | ||||
No., number of positive lesions. *Statistically significant; AFP, α-fetoprotein; MVI, microvascular invasion; AJCC TNM, American Joint Committee on Cancer tumour-node-metastasis.