Table 3.
Enriched functional signalling networks in the protein sets correlating with previous tumour site (A) and distant tissue (B), respectively, upon principal component analysis (PCA), as well as the most abundant proteins (C) that are present in all tissue-derived exosomal samples and do not differ significantly by site of origin.
| A | ||||||||
|---|---|---|---|---|---|---|---|---|
| ID | Description | Gene Ratio | Bg Ratio | p Value | p Adjust | q Value | Gene ID | Count |
| hsa05146 | Amoebiasis | Jun-23 | 102/8081 | 2.96 × 10−7 | 3.11 × 10−5 | 2.65 × 10−5 | C9/C8B/CD14/CTSG/RAB5C/GNAS | 6 |
| hsa05322 | Systemic lupus erythematosus | Jun-23 | 136/8081 | 1.62 × 10−6 | 8.52 × 10−5 | 7.26 × 10−5 | C9/C8B/CTSG/H2AZ1/C6/H3C1 | 6 |
| hsa04610 | Complement and coagulation cascades | Apr-23 | 85/8081 | 8.67 × 10−5 | 3.03 × 10−3 | 2.59 × 10−3 | C9/C8B/F13A1/C6 | 4 |
| hsa05171 | Coronavirus disease—COVID-19 | May-23 | 232/8081 | 4.12 × 10−4 | 1.08 × 10−2 | 9.21 × 10−3 | C9/C8B/RPL12/F13A1/C6 | 5 |
| hsa04614 | Renin–angiotensin system | Feb-23 | 23/8081 | 1.89 × 10−3 | 3.97 × 10−2 | 3.38 × 10−2 | CPA3/CTSG | 2 |
| B | ||||||||
| ID | Description | Gene Ratio | Bg Ratio | p Value | p Adjust | q Value | Gene ID | Count |
| hsa05132 | Salmonella infection | Nov-49 | 249/8081 | 1.97 × 10−7 | 3.05 × 10−5 | 2.74 × 10−5 | DCTN1/RAB5B/MYL9/ARPC2/MAP2K1/ARL8A/DYNLL1/TUBA1C/TUBB2A/ARPC4/CSE1L | 11 |
| hsa04530 | Tight junction | Jun-49 | 169/8081 | 5.08 × 10−4 | 3.91 × 10−2 | 3.50 × 10−2 | MYL9/HSPA4/ARPC2/RAP1A/TUBA1C/ARPC4 | 6 |
| hsa00630 | Glyoxylate and dicarboxylate metabolism | Mar-49 | 30/8081 | 7.58 × 10−4 | 3.91 × 10−2 | 3.50 × 10−2 | GRHPR/MDH1/SHMT1 | 3 |
| hsa05100 | Bacterial invasion of epithelial cells | Apr-49 | 77/8081 | 1.17 × 10−3 | 3.91 × 10−2 | 3.50 × 10−2 | CAV1/ARPC2/SEPTIN9/ARPC4 | 4 |
| hsa04510 | Focal adhesion | Jun-49 | 201/8081 | 1.26 × 10−3 | 3.91 × 10−2 | 3.50 × 10−2 | COL6A2/MYL9/CAV1/RAP1A/MAP2K1/CAPN2 | 6 |
| C | ||||||||
| ID | Description | Gene Ratio | Bg Ratio | p Value | p Adjust | q Value | Gene ID | Count |
| hsa04962 | Vasopressin-regulated water reabsorption | Mar-49 | 44/8081 | 2.33 × 10−3 | 5.35 × 10−2 | 4.80 × 10−2 | DCTN1/RAB5B/DYNLL1 | 3 |
| hsa01240 | Biosynthesis of cofactors | May-49 | 156/8081 | 2.42 × 10−3 | 5.35 × 10−2 | 4.80 × 10−2 | NAPRT/AKR1A1/SHMT1/SPR/MTHFD1 | 5 |
| hsa04610 | Complement and coagulation cascades | Jun-40 | 85/8081 | 3.27 × 10−6 | 2.64 × 10−4 | 2.37 × 10−4 | SERPINA1/A2M/KNG1/VTN/SERPING1/CLU | 6 |
| hsa04979 | Cholesterol metabolism | May-40 | 50/8081 | 4.13 × 10−6 | 2.64 × 10−4 | 2.37 × 10−4 | APOA1/APOE/APOA2/APOC3/APOH | 5 |
| hsa05143 | African trypanosomiasis | Apr-40 | 37/8081 | 3.02 × 10−5 | 1.29 × 10−3 | 1.16 × 10−3 | KNG1/APOA1/HBB/HBA1 | 4 |
| hsa00010 | Glycolysis/Gluconeogenesis | Apr-40 | 67/8081 | 3.15 × 10−4 | 1.01 × 10−2 | 9.04 × 10−3 | PGK1/ALDOA/GAPDH/PKM | 4 |
| hsa01230 | Biosynthesis of amino acids | Apr-40 | 75/8081 | 4.86 × 10−4 | 1.24 × 10−2 | 1.11 × 10−2 | PGK1/ALDOA/GAPDH/PKM | 4 |
| hsa04216 | Ferroptosis | Mar-40 | 41/8081 | 1.05 × 10−3 | 2.24 × 10−2 | 2.01 × 10−2 | CP/TF/FTH1 | 3 |
| hsa04066 | HIF-1 signalling pathway | Apr-40 | 109/8081 | 1.97 × 10−3 | 3.60 × 10−2 | 3.23 × 10−2 | PGK1/TF/ALDOA/GAPDH | 4 |
| hsa01200 | Carbon metabolism | Apr-40 | 118/8081 | 2.63 × 10−3 | 4.21 × 10−2 | 3.77 × 10−2 | PGK1/ALDOA/GAPDH/PKM | 4 |