Figure 1.

Coronal schematic of the brain, depicting normal structures and in LBD subjects. Shading shows the distribution of aSyn in LBs/LNs in cortical and subcortical regions. Subcortical regions are associated with PD, and as the disease progresses to cortical regions it corresponds with DLB and PDD. (Right, A–D): LB pathology (arrows) revealed in the amygdala of a patient with DLB with antibody to pSer¹²⁹ aSyn (A), ubiquitin (B), and whole aSyn counterstained with haematoxylin. (D), LB with a halo typically found in the substantia nigra. Magnification bar: 10μM.