Table 1.
Highest factor loadings of PC2 and PC3 from the Principal Component Analysis (PC2/PC3-correlated genes).
| PC2 Genes | |||||
| Gene | Factor Loading | Gene | Factor Loading | Gene | Factor Loading |
| Il18r1 | 0.742 | Cd8a | 0.683 | Tlr2 | 0.594 |
| Pdcd1lg2 (Pd-l2) e | 0.738 | Cd4 | 0.682 | Cd160 | 0.592 |
| P2rx7 (P2x7) a | 0.733 | Ptges a | 0.679 | Irf1 | 0.591 |
| Bcl2 | 0.723 | Il2rg | 0.678 | Myd88 | 0.585 |
| Gata3 | 0.72 | Ptger4 a | 0.677 | Pla2g4a b | 0.582 |
| Il16 | 0.719 | Tnfrsf18 (Gitr) f | 0.668 | Stat1 | 0.58 |
| Cd3e | 0.718 | Il2rb | 0.653 | Ccl2 | 0.58 |
| Il2ra (Cd25) f | 0.717 | Tnfrsf4 (Ox40) f | 0.652 | Il18bp | 0.577 |
| Lta | 0.713 | Klrd1 (Cd94) c | 0.639 | Irf5 | 0.573 |
| Il10ra | 0.713 | Cd209d c | 0.634 | Tlr4 | 0.572 |
| Cd69 | 0.712 | Itgam | 0.633 | Il6st | 0.572 |
| Akt3 d | 0.707 | Icam1 | 0.632 | Ltb4r1 (Blt1) a | 0.571 |
| Cd28 | 0.706 | Alox12 a | 0.632 | Il1b | 0.569 |
| Il7r (Cd127) | 0.704 | Xcl1 | 0.622 | Nfkb1 | 0.567 |
| Hpgds (Ptgds2) a | 0.704 | Ucp2 | 0.621 | Itgal | 0.567 |
| Mki67 (Ki67) | 0.702 | Pdcd1lg1 (Pd-l1) e | 0.619 | Cxcl9 | 0.567 |
| Ccr4 | 0.701 | Cxcl10 | 0.614 | Nfkb2 | 0.566 |
| Il9r | 0.697 | Ccl22 | 0.614 | Cxcl16 | 0.562 |
| Cxcr4 | 0.693 | Ccr5 | 0.607 | Cxcr6 | 0.552 |
| Ccl19 | 0.689 | Irf7 | 0.605 | Alox5 a | 0.544 |
| Btla | 0.685 | Itgb2 | 0.603 | Rxra b | −0.569 |
| Il18rap | 0.684 | Cd68 | 0.6 | ||
| PC3 Genes | |||||
| Gene | Factor Loading | Gene | Factor Loading | Gene | Factor Loading |
| Il12rb1 | 0.943 | Cxcr2 | 0.825 | Cd83 | 0.63 |
| Il12rb2 | 0.941 | Il27 | 0.803 | Csf2 | 0.619 |
| Nos2 | 0.928 | Cd80 | 0.782 | Ccl4 | 0.614 |
| Ccr7 | 0.914 | Irg1 (acod1) | 0.768 | Havcr2 (Tim-3) e,f | 0.591 |
| Il12b | 0.884 | Tgfb2 | 0.693 | Icosl | 0.574 |
| Ifng | 0.867 | Cxcr3 | 0.663 | Ebi3 (Il27b) | 0.562 |
| Cxcr5 | 0.864 | Ccl7 | 0.657 | Il21r | 0.558 |
| Il23a | 0.842 | Pdcd1 (Pd-1) e,f | 0.643 | ||
| Il21 | 0.839 | Ptgs2 a | 0.64 | ||
M1-associated transcripts are shown in bold; M2-associated transcripts are in italics; a Prostaglandin synthesis; b Lipid Metabolism; c C-type lectin receptors (CRLs); d MAPK signaling pathway; e Inhibitory markers; f Regulatory T cell function.