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. 2021 Jun 24;22(13):6813. doi: 10.3390/ijms22136813

Table 1.

The HER2-positivity definition in aCRC according two different system: the HERACLES criteria and the GEA criteria.

HER2 Positivity in aCRC
The HERACLES Criteria The GEA Criteria

  • 3+ IHC score * in more than 50% of the tumor cells;

    OR

  • 3+ IHC score in 10~50% of the tumor cells and FISH positive;

    OR

  • 2+ IHC score ** in more than 50% of the tumor cells by IHC and FISH positivity ***.

  • 3+ IHC score in more than 10% of the tumor cells;

    OR

  • 2+ IHC score in more than 10% of the tumor cells and FISH positivity *.

HER2: Human epidermal growth factor receptor 2; HERACLES: HER2 Amplification for Colorectal Cancer Enhanced Stratification; GEA: gastroesophageal adenocarcinoma; IHC: immunochemistry; FISH: fluorescent in situ hybridization. * 3+ IHC score is represented by an intense and strong lateral, basolateral, or circumferential membranous HER2 expression. ** 2+ IHC score is represented by a moderate lateral, basolateral, or circumferential membranous HER2 expression. *** FISH positivity is defined as a HER2:CEP17 (chromosome enumeration probe) ratio ≥2.