Figure 3.

RGS14 modulation of G-protein-dependent signaling. RGS14 accelerates Gαi/o deactivation to limit GPCR–Gi/o signaling and disinhibit the adenylyl cyclase activity and downsteram cAMP signaling. Binding of inactive Gαi1/3–GDP localizes and anchors RGS14 to the plasma membrane, where it is optimally positioned to regulate the initial steps of intracellular post synaptic signal transduction. Likewise, it is possible that RGS14 modulation of GPCR signaling influences plastic processes such as AMPAR trafficking.