Figure 4.

RGS14 potential regulation of dendritic spine morphogenesis. RGS14 exists in the brain as a high molecular weight complex with proteins associated with cytoskeletal architecture and dendritic spine morphogenesis, including actin-binding proteins (α-actinin-1, drebrin, gelsolin), myosins (MyoII, MyoV, MyoVI), and CaMKII. Myosins also mediate AMPAR trafficking between the plasma membrane and the soma. Additionally, human/primate RGS14 could possibly interact with postsynaptic density proteins (e.g., Homer1, Shank3) that link actin cytoskeleton to glutamate receptors and scaffold receptors to key signaling molecules.