RGS14 modulation of postsynaptic signaling and plasticity. RGS14 binds many protein partners, directly or indirectly, to regulate signaling events and plasticity in the post synaptic dendritic spine (top) and in the soma where it shuttles in/out of the nucleus (bottom). Key: green line with arrow = activation (increase if inside bubble), red line with T arrow = inhibition, black line with arrow = interaction or relationship (unspecified directionality), dashed gray line = movement, question mark = unknown or uncertain interaction. This key is also used in Figure 3, Figure 4, Figure 5 and Figure 6.