(a/b), Different DVHs (cut-off) for different dose rates (in Gy/min) for IMRT (a) and proton (b) techniques, (c/d) and (e/f), show the accumulated blood volume receiving a threshold dose as a function of the treatment fraction number, (c/d) represent the results of a non-zero threshold dose (D > 0 Gy) and (e/f), show the results of the accumulated high dose threshold of 0.43 Gy (CD8 lymphocytes) for IMRT (left) and proton (right) over the course of treatment.