Table 2.
Univariate regression analysis for the considered parameters in the severe COVID-19 sub-cohort (n = 240) with >10 or ≤10 repeats in the C9orf72 hexanucleotide repeat expansion (HRE) region.
| Normal Values |
≤10 Repeats (n = 213) |
>10 Repeats (n = 27) |
p | |
|---|---|---|---|---|
| Age, year Mean (±SD) |
64.76 (± 11.98) | 60.67 (± 13.37) | 0.090 | |
| AST, U/L Mean (±SD) |
10–50 | 79.73 (± 79.88) | 73.40 (± 46.01) | 0.690 |
| ALT, U/L Mean (±SD) |
18–39 | 74.60 (±94.05) | 59.913 (±29.86) | 0.458 |
| Ferritin, ug/L Mean (±SD) |
30–400 | 1334.82 (±1541.88) | 1125.73 (±756.03) | 0.525 |
| Creatinine, mg/dL Mean (±SD) |
0.7–1.2 | 1.40 (±1.35) | 1.54 (±2.33) | 0.651 |
| Urea, mg/dL Mean (±SD) |
17–49 | 75.97 (±6.06) | 101.00 (±27.67) | 0.228 |
| D-dimer, ng/mL Mean (± SD) |
<232 | 1623.84 (±290.31) | 4552.09 (±2753.16) | 0.020 |
| Albumin, g/L Mean (±SD) |
31.0–52.0 | 32.70 (±0.41) | 33.24 (±0.90) | 0.649 |
| WBC, ×103/uL Mean (±SD) |
4.0–10.8 | 14.32 (±46.77) | 10.28 (±6.27) | 0.679 |
| Lymphocytes, ×103/uL Mean (±SD) |
0.9–4.0 | 1.94 (±0.16) | 1.82 (±0.24) | 0.791 |
| CRP, mg/L Mean (±SD) |
<5.0 | 88.71 (±79.32) | 71.78 (±49.39) | 0.299 |
| Platelets, ×103/uL Mean (±SD) |
130–400 | 343.01(±162.10) | 338.10 (±144.42) | 0.889 |
| MV or NIV, n (%) | 77/213 (36%) | 15/27 (56%) | 0.053 |
SD: standard deviation; ALT: alanine aminotransferase; AST: aspartate aminotransferase; WBC: white blood cells; CRP: C-reactive protein; MV: mechanical ventilation; NIV: non-invasive ventilation.