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. 2021 Jul 2;13(13):3336. doi: 10.3390/cancers13133336

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© 2021 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).

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CT of two synchronous and separate epicenters of histologically confirmed hepatocellular carcinoma and combined hepatocellular cholangiocarcinoma in the same liver (A,B). In particular, the hepatocellular carcinoma was located in the segment VIII of the liver and presented an arterial phase hyperenhancement (A1), followed by an initial wash-out during the portal phase (A2), which became more evident during the late delayed phase (A3). On the contrary, the combined hepatocellular cholangiocarcinoma was located in the segment VI of the liver and showed a strong hyperenhancement during the arterial phase (B1), followed by a persistent enhancement during the portal phase (B2) and no wash-out during the late delayed phase (B3).