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. 2021 Jun 25;22(13):6856. doi: 10.3390/ijms22136856
SIRT3 sirtuin-3
Sirt3Tg transgenic whole body SIRT3 overexpression
WT wild-type
AEC alveolar epithelial cell
AT2 alveolar type II cell
ROS reactive oxygen species
mtDNA mitochondrial DNA
mtOGG1 mitochondrial 8-oxoguanine-DNA glycosylase 1
OGG1 8-oxyguanine DNA glycosylase
BER base excision repair
BALF bronchoalveolar lavage fluid
MnSOD manganese superoxide dismutase
EVs extracellular vesicles
ER endoplasmic reticulum
H&E hematoxylin and eosin
HLF human lung fibroblasts
mtOgg1tg human mitochondria-targeted OGG1 subunit 1-alpha transgene
IPF idiopathic pulmonary fibrosis
IP intra-peritoneal
IT intra-tracheal
MCAT mitochondrial catalase enforced-expression
α-SMA alpha-smooth muscle actin
TGFβ transforming growth factor-beta