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. 2021 Jul 5;13(13):3370. doi: 10.3390/cancers13133370

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© 2021 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).

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Analysis of classical markers for stratification of HNSCC samples. Statistical significance was indicated as * for p < 0.05 and ** for p < 0.0001; (A) viral load quantification of HPV-positive HNSCC samples by qPCR; (B) differential p16 mRNA expression in HNSCC samples analyzed by qPCR; (C) Viral E7 mRNA expression in HPV-positive HNSCC samples; (D) Spearman correlation analyses between the expression of E7 (log₂) oncogene and p16 (log₂) showed correlation (r = 0.59; p < 0.05) in HPV-positive HNSCC tumor samples.