Table 1.

Functional classification of cancer-related proteins identified in ectosomes derived from T-24 urothelial bladder carcinoma cells.

Cell Proliferation (GO:0008283)	Cell Adhesion (GO:0007155)	Cell Migration (GO:0016477)	Angiogenesis (GO:0001525)	Immune Response (GO:0006955)	Drug Response (GO:0042493)
Double-strand break repair protein MRE11 (MRE11) Annexin A7 (ANXA7) Guanine nucleotide-binding protein G(i) subunit alpha-2 (GNAI2) Ras-related C3 botulinum toxin substrate 1 (RAC1) DAZ-associated protein 1 (DAZAP1) Myosin-10 (MYH10) Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1 (GNB1) Interleukin-18 (IL18) Thioredoxin reductase 1, cytoplasmic (TXNRD1) X-ray repair cross-complementing protein 5 (XRCC5)	ADP-ribosylation factor 6 (ARF6) Amyloid-beta precursor protein (APP) Catenin alpha-1 (CTNNA1) Catenin beta-1 (CTNNB1) CCN family member 1 (CCN1) CD166 antigen (ALCAM) CD44 antigen (CD44) Cell surface glycoprotein MUC18 (MCAM) Collagen alpha-1(XVIII) chain (COL18A1) EGF-like repeat and discoidin I-like domain-containing protein 3 (EDIL3) Ephrin type-A receptor 2 (EPHA2) Flotillin-2 (FLOT2) Intercellular adhesion molecule 1 (ICAM1) Neural cell adhesion molecule L1 (L1CAM) Ras-related C3 botulinum toxin substrate 1 (RAC1) Sarcoplasmic/endoplasmic reticulum calcium ATPase 2 (ATP2A2) Sodium/potassium-transporting ATPase subunit beta-1 (ATP1B1) Sphingosine 1-phosphate receptor 1 (S1PR1) Transforming growth factor beta-1-induced transcript 1 protein (TGFB1I1) Transmembrane 9 superfamily member 4 (TM9SF4)	Asparagine--tRNA ligase, cytoplasmic (NARS1) CD44 antigen (CD44) Coronin-1B (CORO1B) Coronin-1C (CORO1C) Ephrin type-A receptor 2 (EPHA2) Fascin (FSCN1) Microtubule-associated protein RP/EB family member 1 (MAPRE1) Neural cell adhesion molecule L1 (L1CAM) Pre-mRNA-processing factor 40 homolog A (PRPF40A) Rho-related GTP-binding protein RhoC (RHOC) Sphingosine 1-phosphate receptor 1 (S1PR1) Transforming protein RhoA (RHOA)	Caveolin-1 (CAV1) Cell surface glycoprotein MUC18 (MCAM) Collagen alpha-1(XVIII) chain (COL18A1) Collagen alpha-2(IV) chain (COL4A2) E3 ubiquitin-protein ligase RNF213 (RNF213) Endoplasmic reticulum aminopeptidase 1 (ERAP1) Interleukin-18 (IL18) Programmed cell death protein 6 (PDCD6) Sphingosine 1-phosphate receptor 1 (S1PR1) Tryptophan-tRNA ligase, cytoplasmic (WARS1)	Complement component 1 Q subcomponent-binding protein, mitochondrial (C1QBP) Deoxynucleoside triphosphate triphosphohydrolase SAMHD1 (SAMHD1) HLA class I histocompatibility antigen, A alpha chain (HLA-A) Interferon-induced transmembrane protein 3 (IFITM3) Purine nucleoside phosphorylase (PNP)	116 kDa U5 small nuclear ribonucleoprotein component (EFTUD2) CAD protein (CAD) Nucleoside diphosphate kinase A (NME1) Transferrin receptor protein 1 (TFRC)