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. 2021 Jul 8;27:73. doi: 10.1186/s10020-021-00330-2

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© The Author(s) 2021

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 2 — CircMTO1 inhibited the proliferation and migration and induced the apoptosis of ox-LDL-stimulated VSMCs. A The mRNA expression levels of circMTO1 and MTO1 in VSMCs transfected with pcDNA 3.1-circMTO1. B, C The effect of circMTO1 overexpression on cell viability and proliferation determined by CCK8 and BrdU incorporation assays. D The effect of circMTO1 overexpression on apoptosis. E The effect of circMTO1 on cell migration. **P < 0.01, ^#P < 0.05 compared with NC + ox-LDL + capecitabine. Ca. indicates the capecitabine