Fig. 5.

Effect of miR-182-5p overexpression or RASA1 knockdown on circMTO1-induced proliferation, apoptosis and migration of VSMCs. A Viability of VSMCs co-transfected with circMTO1 vector and miR-182-5p mimic or si-RASA1. B Proliferation of VSMCs co-transfected with circMTO1 vector and miR-182-5p mimic or si-RASA1. C Apoptosis of VSMC co-transfected with circMTO1 vector and miR-182-5p mimic or si-RASA1. D Migration of VSMCs co-transfected with circMTO1 vector and miR-182-5p mimic or si-RASA1. * vs NC (OX-LDL) + capecitabine group, ^# vs circMTO1(OX-LDL) + capecitabine group. Ca. indicates the capecitabine. ** P < 0.01, #P < 0.05. E Western Blot results of capase3, cyclinD1, RASA1 and GADPH in VSMCs co-transfected with circMTO1 vector and miR-182-5p mimic or si-RASA1. * vs NC group, ^# vs circMTO1 group. *** P < 0.001, ** P < 0.01, ^#P < 0.05