Table 1.

Pharmacokinetic parameters (mean ± SEM) after single intraperitoneal/oral dose of three (1, 2 & 3) chalcone derivatives

Pharmacokinetic Parameters	Derivative 1 (mean ± SEM)	Derivative 2 (mean ± SEM)	Derivative 3 (mean ± SEM)
Administered Dose (mg/1.5 kg Rabbits)	5.46	7.28	5.46
Administration Route	Intraperitoneal	Oral	Oral
C0 (µg/mL)	0.966 ± 0.025	0.986 ± 0.004	0.944 ± 0.007
Cmax (µg/mL)	1.96 ± 0.46	69.89 ± 5.49	3.74 ± 1.64
tmax (h)	0.33 ± 0.05	3.4 ± 0.79	2.83 ± 0.87
t1/2 (h)	12.60 ± 2.09	93.32 ± 32.59	13.30 ± 1.67
AUC0–48 (µg.h/mL)	2.94 ± 0.83	3755.16 ± 738.71	14.16 ± 3.78
Ke	− 0.035 ± 0.026	− 0.013 ± 0.004	− 0.056 ± 0.007
CL (mL/min)	0.28 ± 0.08	0.15 ± 0.05	0.53 ± 0.10
Vd (L)	7.31 ± 0.29	10.72 ± 0.66	9.12 ± 0.73

C₀ Concentration of administrated drug at time zero, C_max Peak plasma concentration, t_max time to reach the peak plasma concentration, t_1/2 elimination half-life, AUC Area under the total plasma concentration–time curve, K_e Elimination rate constant, CL Plasma clearance, V_d Volume of distribution