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. 2021 Jul 1;22(13):7145. doi: 10.3390/ijms22137145

Figure 4.

Figure 4

Alleviation of psoriasis-like symptoms in mouse ears by inhibiting ANO1. To induce psoriasis-like skin injury, three mouse groups (IMQ [n = 7], IMQ + 30 µM A01 [n = 7], and IMQ + 100 µM A01 [n = 7]) received a daily dose of 25 mg of 5% IMQ cream on their right ears for 7 consecutive days; IMQ + 30 µM A01 and IMQ + 100 µM A01 groups additionally received 15 µL of 30 µM and 100 µM A01, respectively, at 30 min before and after IMQ treatment. The control group received a similar dose of Vaseline cream on their right ears. (a) Changes in right ear thickness caused by IMQ and A01. (b–d) Thickness, erythema, and scaling of right ears were scored daily. (e) The cumulative score (thickening plus erythema plus scaling) was described. Symbols per day depict mean ± SEM of seven mice ears per group. The significant differences among groups obtained from statistical analysis are presented in Figure S2. (f) Phenotypic representation of the right ears in mice treated with IMQ or IMQ + 100 µM A01 for 7 days. Imiquimod, IMQ; T16Ainh-A01, A01.