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Motor tests in rats co-injected with AAV-α-synA53T and AAV-GFP or AAV-α-synA53T and AAV-ΔLRRK2G2019S (ΔLRRK2GS). (A) Rats were tested using the cylinder test at 6 and 15 weeks PI to detect asymmetry in forepaw use. (B) Rats were injected with methamphetamine (2.5 mg/kg) to induce hyper-locomotion. Results are expressed as the means ± SEM. N = 8–12 animals/group. ANOVA and PLSD post hoc test. * p < 0.05, ** p < 0.01, *** p < 0.001.
