Figure 7.

Measurement of the SNpc volume transduced by AAV-ΔLRRK2^G2019S and the dead kinase form ΔLRRK2^{G2019S/D1994A}. (A) Confocal images to delineate the SNpc based on TH staining (in red), reported in the green channel, corresponding to the α-syn immunofluorescence when co-expressed with ΔLRRK2^G2019S (ΔLRRK2^GS) or ΔLRRK2^DK, the dead kinase form ΔLRRK2^{G2019S/D1994A}. Scale bar: 1000 µm. (B) Quantification of the fraction (%) of the SNpc expressing α-syn protein after co-transduction with ΔLRRK2^G2019S or ΔLRRK2^{G2019S/D1994A}. Results are expressed as the means ± SEM. N = 8 animals/group. No statistical difference, Student’s t-test.